| Opaleye Management Inc.10% owner · 59 transactions | — | 10.13M† | — | 5.26M | 2.66M |
| Sulat James RDirector, 10% owner · 3 transactions | — | 5.96Mas of Apr 2010 | — | — | — |
| Equilon Enterprises LLC10% owner · 1 transaction | — | 5.57Mas of May 2011 | — | — | — |
| Ispagnac Participacoes Ltda. +1 co-filer10% owner · 1 transaction | — | 5.57Mas of Jun 2011 | — | — | — |
| Shell Brazil Holding B.V.10% owner · 1 transaction | — | 5.57Mas of May 2011 | — | — | — |
| Vivo Ventures VII, LLC +2 co-filers10% owner · 12 transactions | — | 4.23M†as of Sep 2017 | — | — | 1.34M |
| Biomedical Sciences Investment Fund Pte Ltd. +1 co-filer10% owner · 1 transaction | — | 3.36Mas of Apr 2010 | — | — | — |
| Shaw AlanPresident and CEO, Director · 26 transactions | — | 1.05M†as of Dec 2011 | 365.0K | 2.0K | 181.7K |
| Equilon Enterprises LLC +1 co-filer10% owner · 3 transactions | — | 789.5Kas of Apr 2010 | — | — | — |
| Nicols John JDirector · 103 transactions | — | 784.0Kas of Apr 2023 | 2.75M | 101.0K | 1.27M |
| Dilly Stephen GeorgeDirector · 11 transactions | — | 727.1K | 717.6K | 58.5K | 55.1K |
| Maxygen Inc10% owner · 6 transactions | — | 524.6Kas of Dec 2010 | — | — | — |
| Moore AlisonPresident and CEO, Director · 10 transactions | — | 250.5K | 260.6K | — | 10.1K |
| Sheehy Douglas T.See Remarks · 16 transactions | — | 247.6Kas of Mar 2016 | 379.6K | 1.0K | 3.8K |
| Kelley Bernard JDirector · 32 transactions | — | 226.1Kas of Aug 2021 | 326.2K | — | 145.0K |
| Dorgan Byron LDirector · 28 transactions | — | 223.6Kas of Jun 2024 | 415.3K | — | 191.7K |
| Smith David VDirector · 17 transactions | — | 194.3K†as of Jun 2025 | 204.3K | — | 6.0K |
| Norrett KevinChief Operating Officer · 7 transactions | — | 177.3Kas of Feb 2025 | 185.2K | 9.0K | 16.9K |
| Ryali SriramChief Financial Officer · 3 transactions | — | 175.8Kas of Jan 2024 | 164.1K | 11.7K | — |
| Parker H StewartDirector · 4 transactions | — | 143.6Kas of Jun 2025 | 143.6K | — | — |
| Wolf Dennis PDirector · 46 transactions | — | 139.0K | 409.6K | — | 270.6K |
| Singhvi RahulDirector · 4 transactions | — | 137.1Kas of Jun 2025 | 137.1K | — | — |
| Lalonde JamesSVP, R&D · 34 transactions | — | 135.8Kas of May 2019 | 211.3K | — | 126.1K |
| Sangster GordonSVP & Chief Financial Officer · 21 transactions | — | 134.5Kas of Mar 2019 | 492.9K | — | 192.5K |
| Fitzgerald Margaret NellSee Remarks · 6 transactions | — | 133.8Kas of Jan 2024 | 137.6K | 11.8K | 15.7K |
| Lutz StefanChief Scientific Officer · 3 transactions | — | 130.4K | — | — | 13.0K |
| Martinborough EstherDirector · 6 transactions | — | 129.0Kas of Jun 2025 | 129.0K | — | — |
| Collins CynthiaDirector · 2 transactions | — | 112.2Kas of Jun 2025 | 112.2K | — | — |
| O'Toole David DSVP & Chief Financial Officer · 7 transactions | — | 110.7Kas of Sep 2013 | 95.4K | 20.0K | — |
| Anton David L.SVP, BioIndustrials · 6 transactions | — | 93.8Kas of Feb 2013 | 103.5K | 2.0K | 3.8K |
| Sarret Joseph J.SVP and CBO · 3 transactions | — | 87.3K†as of Mar 2012 | 72.0K | 2.0K | — |
| Richards ChristosDirector · 2 transactions | — | 85.1Kas of Jun 2025 | 85.1K | — | — |
| De Vre RaymondDirector · 4 transactions | — | 84.8K | 88.8K | — | 4.0K |
| Tobin MatthewSVP, Research & Development · 3 transactions | — | 78.7Kas of May 2013 | 34.5K | — | — |
| Karsner AlexanderDirector · 2 transactions | — | 78.5Kas of Jan 2014 | 78.5K | — | — |
| Cheng Pam P.Director · 9 transactions | — | 69.6Kas of Jun 2019 | 108.8K | — | 39.2K |
| Glaub Kathleen SeredaDirector · 9 transactions | — | 68.5Kas of Jun 2019 | 113.1K | — | 44.6K |
| Erbez GeorgiaSee Remarks · 4 transactions | — | 66.8K | 76.9K | — | 10.1K |
| Aaker JenniferDirector · 4 transactions | — | 66.2Kas of Jun 2023 | 66.2K | — | — |
| Strumph Peter MInterim President and CEO · 4 transactions | — | 60.8Kas of Jun 2012 | 40.8K | — | — |
| Seufer-Wasserthal PeterSVP, Pharmaceuticals · 1 transaction | — | 55.0Kas of Jan 2013 | 38.1K | — | — |
| Yang Patrick YDirector · 36 transactions | — | 53.8Kas of Jun 2022 | 204.1K | 186.0K | 356.3K |
| Lawson Robert JSVP and CFO · 3 transactions | — | 44.0Kas of May 2011 | 40.0K | 4.0K | — |
| Taylor Dean Ross JrAdvisor · 10 transactions | — | 38.6Kas of Feb 2023 | 47.7K | — | — |
| Baruch Thomas RDirector · 33 transactions | — | 33.1Kas of Jun 2020 | 205.5K | 2.5K | 174.9K |
| Dowd Brian PaulInterim CFO · 3 transactions | — | 28.3Kas of Jun 2012 | 4.4K | — | — |
| Aldridge Michael D.See Remarks · 4 transactions | — | 22.0Kas of May 2018 | 44.0K | — | 44.0K |
| Pasternack Bruce ADirector · 3 transactions | — | 10.0Kas of Aug 2010 | — | 10.0K | — |
| Cmea Ventures Life Sciences 2000 LP +4 co-filersDirector, 10% owner, 10% owner · 8 transactions | — | 0†as of Nov 2014 | — | — | 2.92M |