| Rosen David Efraim +1 co-filer10% owner · 1 transaction | — | 6.29M†as of Aug 2025 | — | — | 25.0K |
| Enright Patrick G +4 co-filers10% owner · 6 transactions | — | 2.32M†as of Dec 2017 | — | 200.0K | 1.00M |
| Kaneko Yasunori10% owner · 2 transactions | — | 2.15M†as of Dec 2017 | — | — | — |
| Skyline Venture Partners V LP +1 co-filer10% owner · 1 transaction | — | 2.15Mas of Dec 2017 | — | — | — |
| Kaneko Yasunori +2 co-filers10% owner · 4 transactions | — | 1.94Mas of May 2015 | — | 150.0K | — |
| Bonderman David +2 co-filersFormer 10% Owner · 2 transactions | — | 1.23Mas of May 2015 | — | 100.0K | — |
| Every Nathan R +6 co-filers10% owner · 5 transactions | — | 582.5Kas of May 2015 | — | 150.0K | — |
| Heron Patrick JDirector, 10% owner · 5 transactions | — | 582.5Kas of May 2015 | — | 150.0K | — |
| Ciaffoni JosephPresident and CEO, Director · 94 transactions | — | 526.3Kas of Feb 2024 | 1.57M | — | 760.2K |
| Brannelly PaulExecutive Vice President & CFO · 37 transactions | — | 221.4Kas of Feb 2021 | 166.6K | 10.0K | 10.0K |
| Freund John GordonDirector · 29 transactions | — | 195.0K† | 94.7K | 150.0K | 22.4K |
| Karnani VikramPresident and CEO, Director · 5 transactions | — | 176.6K | 217.8K | — | — |
| Tupper ColleenEVP & Chief Financial Officer · 32 transactions | — | 147.3K | 365.7K | — | 108.2K |
| Fleming Alison BEVP & Chief Technical Officer · 63 transactions | — | 143.7Kas of Aug 2021 | 259.6K | — | 92.2K |
| Malamut RichardEVP and Chief Medical Officer · 12 transactions | — | 130.3Kas of Feb 2022 | 144.9K | — | — |
| Santini GinoDirector · 12 transactions | — | 112.5K | 94.7K | — | 5.4K |
| Kuhlmann Shirley R.EVP and General Counsel · 53 transactions | — | 108.1Kas of Mar 2025 | 507.1K | — | 283.2K |
| Fallon John A.Director · 12 transactions | — | 99.5K | 97.1K | 2.4K | 34.9K |
| Smith Thomas BEVP and Chief Medical Officer · 16 transactions | — | 85.3K | 142.7K | — | 28.1K |
| Dieter DavidEVP & General Counsel · 7 transactions | — | 77.1K | 99.6K | — | 20.2K |
| Dreyer ScottEVP & Chief Commercial Officer · 72 transactions | — | 75.3K | 556.1K | — | 349.2K |
| Bohlin Garen GDirector · 13 transactions | — | 71.0K | 108.7K | — | 37.7K |
| Balice-Gordon Rita J.Director · 8 transactions | — | 61.4K | 65.0K | — | 3.6K |
| Melincoff Gwen ADirector · 7 transactions | — | 52.5Kas of May 2024 | 52.5K | — | — |
| Heffernan Michael ThomasDirector · 87 transactions | — | 50.3Kas of Feb 2025 | 798.0K | — | 1.22M |
| McFarlane Neil F.Director · 4 transactions | — | 49.4Kas of May 2024 | 49.4K | — | — |
| Paya Carlos VDirector · 2 transactions | — | 28.3K | 28.3K | — | — |
| Lurker NancyDirector · 4 transactions | — | 26.8K | 31.3K | — | 4.5K |
| Hirsch DavidDirector · 16 transactions | — | 21.2Kas of May 2020 | 30.9K | 200.0K | 1.05M |
| Duke Barry SSee remarks · 5 transactions | — | 20.1Kas of Mar 2017 | 20.5K | — | — |
| Glancy Donovan MichaelDirector · 1 transaction | — | 17.5K | 17.5K | — | — |
| Schroeder Theodore RDirector · 3 transactions | — | 11.0Kas of May 2020 | 11.0K | — | — |