| Sanofi10% owner · 5 transactions | — | 10.55Mas of May 2017 | — | 1.14M | — |
| Novartis Ag +1 co-filer10% owner · 4 transactions | — | 4.05Mas of Sep 2012 | — | 335.0K | 1.55M |
| Atlas Venture Associates V LP +7 co-filers10% owner · 16 transactions | — | 1.00M†as of Feb 2006 | — | — | 183.0K |
| Barrett PeterDirector · 54 transactions | — | 503.5K†as of Mar 2006 | — | — | 833.9K |
| Schimmel PaulDirector · 64 transactions | — | 317.0K†as of Mar 2018 | 142.8K | 193.0K | 253.8K |
| Sharp Phillip ADirector · 33 transactions | — | 278.1K†as of Jan 2025 | 179.9K | — | 179.9K |
| Sharp Philip ADirector · 43 transactions | — | 270.1K†as of Apr 2019 | 240.0K | 14.3K | 240.0K |
| Maraganore JohnChief Executive Officer, Director · 409 transactions | — | 231.1K†as of Dec 2021 | 1.97M | 21.0K | 1.65M |
| Greene Barry EPresident · 166 transactions | — | 219.1K†as of Sep 2020 | 676.6K | 4.6K | 659.6K |
| Greenstreet YvonneChief Executive Officer, Director · 240 transactions | — | 98.8K† | 573.4K | — | 405.3K |
| Poulton Jeffrey V.EVP, Chief Financial Officer · 153 transactions | — | 63.2K† | 96.4K | — | 28.1K |
| Tanguler TolgaEVP, Chief Commercial Officer · 149 transactions | — | 34.3K | 68.7K | — | 31.1K |
| Bonney Michael WDirector · 30 transactions | — | 32.1K†as of Aug 2025 | 75.8K | 4.0K | 58.9K |
| Pyott David E IDirector · 18 transactions | — | 30.0K† | 45.3K | 27.9K | 43.7K |
| Vaishnaw AkshayPresident · 212 transactions | — | 26.6K†as of Aug 2023 | 597.1K | — | 546.6K |
| Schulman Amy WDirector · 11 transactions | — | 24.0K | 54.2K | — | 30.2K |
| Garg PushkalEVP Chief R&D · 211 transactions | — | 21.1K† | 144.4K | — | 131.8K |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research · 167 transactions | — | 21.1K† | 67.6K | — | 59.9K |
| Reid LaurenceSVP, Chief Business Officer · 33 transactions | — | 19.9K†as of Jan 2015 | 105.5K | 930 | 80.9K |
| Supran BryanEVP, CLO and Secretary · 2 transactions | — | 14.6K | 14.6K | — | — |
| McLaughlin MelissaChief Human Resources Officer · 14 transactions | — | 13.4K | — | — | 3.9K |
| Clarke John KDirector · 12 transactions | — | 11.1Kas of May 2018 | 50.0K | — | 50.0K |
| Hesslein Robert W.EVP, CLO and Secretary · 2 transactions | — | 8.0Kas of Mar 2025 | 8.0K | — | — |
| Keating LaurieEVP, Chief Legal Officer · 82 transactions | — | 5.6K†as of Aug 2021 | 211.2K | 11.5K | 210.9K |
| Ausiello Dennis ADirector · 49 transactions | — | 5.1K† | 138.6K | — | 150.2K |
| Franchini Indrani LallEVP, CLO & Secretary · 16 transactions | — | 4.1Kas of Feb 2024 | 11.2K | — | 7.1K |
| Mason MichaelVP, Finance and Treasurer · 79 transactions | — | 3.7K†as of Aug 2018 | 185.8K | — | 178.7K |
| Sigal Charles ElliottDirector · 2 transactions | — | 3.4K† | 1.4K | — | — |
| Paul Steven MDirector · 16 transactions | — | 3.3Kas of Apr 2022 | 60.0K | 1.0K | 60.0K |
| Hamburg Margaret ADirector · 3 transactions | — | 1.6K | 1.6K | — | — |
| Reitan Colleen FDirector · 22 transactions | — | 1.4K | 19.4K | 36 | 18.0K |
| Brandicourt OlivierDirector · 2 transactions | — | 1.4K | 1.4K | — | — |
| Kellogg Peter NDirector · 2 transactions | — | 1.4K | 1.4K | — | — |
| Allen Patricia LVP of Finance/Treasurer · 54 transactions | — | 1.2Kas of Dec 2010 | 45.0K | — | 45.0K |
| Gros David-Alexandre CSVP, Chief Business Officer · 2 transactions | — | 1.0Kas of Feb 2016 | — | 1.0K | — |
| Starr Kevin PDirector · 29 transactions | — | 900as of Nov 2015 | 217.6K | — | 217.6K |
| Bertozzi Carolyn RDirector · 1 transaction | — | 775as of May 2025 | 775 | — | — |
| Arbuckle Stuart ADirector · 1 transaction | — | 671 | 671 | — | — |
| Fanucci MarshaDirector · 11 transactions | — | 136as of Feb 2023 | 75.1K | 10.0K | 85.0K |
| Soni Manmeet SinghChief Financial Officer · 5 transactions | — | 83as of Jul 2018 | — | — | — |
| Vincent James LDirector · 14 transactions | — | 0as of Jun 2010 | 75.0K | — | 85.0K |