Ionis Pharmaceuticals, Inc.
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A biotechnology company in Carlsbad, California, that makes RNA-targeted medicines using antisense technology — drugs that "turn off" disease-causing genes. Its best-known product is Spinraza, the first treatment for spinal muscular atrophy, developed with Biogen. Founded in 1989 as Isis Pharmaceuticals (named after the Egyptian goddess), it renamed itself Ionis in 2015 to shake off confusion with the terrorist group of the same name.
1.00% Convertible Senior Notes due 2021
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