Karyopharm Therapeutics Inc.
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A biopharmaceutical company that makes cancer drugs, best known for XPOVIO (selinexor), an oral pill for blood cancers like multiple myeloma and lymphoma. Its medicines work by a novel mechanism that blocks a protein from shuttling tumor-suppressor proteins out of the cell nucleus, letting them do their job. Founded in 2008 by Dr. Sharon Shacham, a cancer researcher, and Dr. Michael Kauffman, the company's name blends the Greek word "karyon" (nucleus) with "pharm" — a nod to its nuclear-targeting science.
3.00% Convertible Senior Notes Due 2025
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