| Funicular Funds, LPReporting owner · 2 transactions | — | 7.74M†as of Jul 2022 | — | — | — |
| mccormack riley10% owner · 7 transactions | — | 4.42M†as of Jan 2015 | — | 1.00M | 900.0K |
| Koh Bong Y +6 co-filers10% owner · 5 transactions | — | 4.03Mas of Feb 2025 | — | 122.9K | — |
| Ma-Weaver Jacob +1 co-filerDirector · 1 transaction | — | 4.00Mas of Dec 2022 | — | — | — |
| Fairmount Funds Management LLC +4 co-filersDirector, 10% owner · 1 transaction | — | 3.71M† | 333.3K | — | — |
| Fairmount Funds Management LLC +3 co-filersDirector, 10% owner · 2 transactions | — | 3.37M†as of Nov 2024 | 435.0K | — | — |
| Ma-Weaver Jacob +1 co-filerSee Footnote 1 · 26 transactions | — | 2.58Mas of May 2022 | — | 757.8K | — |
| Janus Henderson Group PLC +1 co-filer10% owner · 15 transactions | — | 2.12Mas of Aug 2024 | — | 634.7K | — |
| Formela Jean FrancoisDirector, 10% owner · 2 transactions | — | 1.58Mas of Oct 2012 | 317.4K | — | 140.0K |
| Atlas Venture Fund VII L P10% owner · 1 transaction | — | 1.34Mas of Mar 2010 | — | — | 140.0K |
| Klein Lawrence OttoChief Executive Officer, Director · 3 transactions | — | 925.6K | 76.7K | — | 3.5K |
| Lowe David GeorgeDirector · 10 transactions | — | 810.3K†as of Jul 2009 | — | — | 405.6K |
| Grais Linda SDirector · 2 transactions | — | 679.1Kas of Mar 2010 | — | — | 210.8K |
| Boulder Ventures IV Annex LP +7 co-filers10% owner · 4 transactions | — | 676.5K†as of Apr 2009 | — | — | — |
| Skyline Venture Partners Qualified Purchaser Fund IV L PFormer 10% owner · 7 transactions | — | 335.4Kas of Jun 2009 | — | — | 199.8K |
| Sandler Laura LeeChief Operating Officer · 17 transactions | — | 236.4K | 47.5K | — | 24.2K |
| Zabriskie John LDirector · 1 transaction | — | 156.1Kas of Oct 2012 | 127.0K | — | — |
| Wheeler Patrick MChief Financial Officer · 3 transactions | — | 101.5Kas of Sep 2014 | 109.2K | — | 8.2K |
| Edwards Larry ToddChief Commercial Officer · 1 transaction | — | 100.0K | 100.0K | — | — |
| Ozeroff Christopher DavidS.V.P., General Counsel · 14 transactions | — | 51.0Kas of Dec 2021 | 200.8K | 50.0K | 4.0K |
| Conway Robert EReporting owner · 8 transactions | — | 50.0Kas of Jan 2024 | — | 83.1K | — |
| Keuer Thomas AChief Operating Officer · 12 transactions | — | 40.7Kas of Dec 2022 | 65.3K | — | 5.0K |
| Dekker C. JeffreyChief Financial Officer · 1 transaction | — | 40.0Kas of Dec 2022 | 40.0K | — | — |
| Goncalves JoanaChief Medical Officer · 37 transactions | — | 39.0K | 81.5K | — | 50.6K |
| Dambkowski CarlDirector · 9 transactions | — | 38.7K | 62.3K | — | 140.0K |
| Perry Mark LDirector · 5 transactions | — | 35.8Kas of Sep 2006 | 65.8K | — | — |
| Quinlan Paul TGeneral Counsel · 3 transactions | — | 31.0K | 32.5K | — | 1.5K |
| Levy Michael DExecutive Vice President · 6 transactions | — | 20.8Kas of Aug 2007 | — | — | — |
| Titus GaryChief Acct.Officer · 16 transactions | — | 16.6Kas of Aug 2006 | 75.8K | — | 75.8K |
| Agarwal ArjunSenior Vice President, Finance · 16 transactions | — | 15.3K | 34.8K | — | 22.1K |
| Falberg Kathryn ECFO and COO · 11 transactions | — | 12.7Kas of Jun 2009 | — | — | 21.0K |
| Bristow Michael RPres. & Chief Executive Offic, Director · 16 transactions | — | 8.5K†as of Dec 2021 | 1.07M | 1.07M | 26.0K |
| Love Ted WDirector · 8 transactions | — | 3.6Kas of May 2008 | — | 29.0K | — |
| Bendekgey E LeeCFO and Treasurer · 13 transactions | — | 1.5Kas of Nov 2008 | — | — | — |
| Mitchell Daniel JDirector · 1 transaction | — | 611as of Jan 2024 | — | 11.0K | — |
| Wolff Henry WardSr. VP Finance and CFO · 1 transaction | — | 229as of Nov 2006 | — | — | — |
| Koh Bong Y +7 co-filers10% owner · 2 transactions | — | 0as of Feb 2018 | — | — | 1.54M |
| Barris Peter J10% owner · 1 transaction | — | 0as of Feb 2018 | — | — | 1.46M |
| Baskett Forest10% owner · 1 transaction | — | 0as of Feb 2018 | — | — | 1.46M |
| Florence Anthony A. Jr.10% owner · 1 transaction | — | 0as of Feb 2018 | — | — | 1.46M |
| Growth Equity Opportunities IV, LLC +3 co-filers10% owner · 1 transaction | — | 0as of Feb 2018 | — | — | 1.46M |
| Makower Joshua10% owner · 1 transaction | — | 0as of Feb 2018 | — | — | 1.46M |
| Mott David M10% owner · 1 transaction | — | 0as of Feb 2018 | — | — | 1.46M |
| Sandell Scott D10% owner · 1 transaction | — | 0as of Feb 2018 | — | — | 1.46M |
| Sakoda Jon10% owner · 1 transaction | — | 0as of Feb 2018 | — | — | 1.46M |
| Sonsini Peter W.10% owner · 1 transaction | — | 0as of Feb 2018 | — | — | 1.46M |
| Viswanathan Ravi10% owner · 1 transaction | — | 0as of Feb 2018 | — | — | 1.46M |
| Sobel Burton EDirector · 11 transactions | — | 0as of Nov 2006 | 25.0K | — | 37.5K |
| Selby Brian L.VP, Finance · 10 transactions | — | 0as of Apr 2018 | 23.4K | — | 5.9K |