| Haywood George WeaverSee remarks below · 30 transactions | — | 9.24M†as of Aug 2009 | — | 2.14M | 640.0K |
| Eastbourne Capital Management LLC/CA10% owner · 5 transactions | — | 5.66Mas of Mar 2010 | — | — | 4.43M |
| Barry RichardDirector · 28 transactions | — | 3.23M† | 70.0K | 140.0K | 135.0K |
| kole RyszardSVP/Discovery Research · 5 transactions | — | 1.86Mas of Feb 2010 | 21.4K | — | 119.0K |
| Ingram Douglas SChief Executive Officer, Director · 22 transactions | — | 659.8K | 874.1K | 184.4K | — |
| Hudson LeslieFormer CEO · 65 transactions | — | 568.0Kas of Jul 2010 | 2.41M | — | 1.69M |
| Chambers Michael AndrewDirector · 19 transactions | — | 504.0K† | 27.5K | 208.8K | — |
| Weller Dwight DSr. VP Chemistry & Mfg. · 1 transaction | — | 364.6K†as of Feb 2010 | 28.9K | — | — |
| Rodino-Klapac LouisePresident, R&D and Tech Ops · 39 transactions | — | 225.3K | 263.0K | 3.8K | — |
| Behrens M KathleenDirector · 37 transactions | — | 224.4K† | 137.8K | 201.5K | 15.0K |
| Estepan Ian MichaelChief Operating Officer · 45 transactions | — | 202.0K | 246.3K | — | 20.4K |
| Burger Denis RCEO, Director · 2 transactions | — | 171.0Kas of Nov 2006 | 7.5K | — | — |
| Rothfuss CristinEVP, General Counsel · 15 transactions | — | 137.5K | 129.2K | — | — |
| Wong Ryan Ho-YanChief Financial Officer · 9 transactions | — | 135.1K | 118.9K | — | — |
| Iversen Patrick LSr VP of Research & Devlopment · 5 transactions | — | 98.3K†as of Feb 2010 | 35.7K | — | — |
| Howton David TEVP, General Counsel · 64 transactions | — | 92.0Kas of Jun 2020 | 383.7K | — | 329.4K |
| Timmins Alan PPresident & COO, Director · 2 transactions | — | 71.4K†as of Mar 2008 | 7.2K | — | — |
| Kaye Edward M. MDDirector · 26 transactions | — | 71.2Kas of Aug 2017 | 218.5K | 800 | 99.1K |
| Boyle J David IICEO · 3 transactions | — | 70.3Kas of Aug 2010 | 46.3K | 24.0K | — |
| Chase Anthony RDirector · 31 transactions | — | 67.2Kas of Feb 2015 | 8.8K | 265.6K | 53.0K |
| Shrewsbury Stephen BSVP/Regulatory Affairs · 1 transaction | — | 60.0Kas of Feb 2010 | 60.0K | — | — |
| Nicaise ClaudeDirector · 15 transactions | — | 48.4K | 57.7K | — | 2.5K |
| Price Ben GilDirector · 17 transactions | — | 42.8Kas of Mar 2016 | 14.8K | 163.0K | — |
| Wigzell Hans Lennart RudolfDirector · 41 transactions | — | 42.1K | 140.1K | — | 93.8K |
| Aphale JayantVP, Technical Operations · 7 transactions | — | 37.0K†as of Sep 2016 | 37.4K | — | 50.9K |
| Ruff ShamimSVP, Chief Regulatory Affairs · 22 transactions | — | 33.2Kas of May 2018 | 57.7K | — | 40.9K |
| Mahatme SandeshEVP, CFO & CBO · 67 transactions | — | 32.3K†as of Jul 2020 | 619.3K | 5.0K | 442.5K |
| Murray DallanChief Customer Officer · 12 transactions | — | 29.9Kas of Mar 2025 | 37.5K | — | 3.6K |
| Christopher Nishan GarabedianPresident and CEO, Director · 4 transactions | — | 29.6Kas of Feb 2015 | 81.7K | 430.8K | — |
| O'Neill Gilmore NeilEVP, R&D & CMO · 5 transactions | — | 28.5Kas of Mar 2021 | 33.7K | — | — |
| Boor Kathryn JeanDirector · 7 transactions | — | 25.1K | 27.5K | — | 2.4K |
| Arif BilalChief Tech Ops Officer · 33 transactions | — | 24.2Kas of Mar 2025 | 42.5K | — | 13.8K |
| Brown Ryan EdwardEVP, General Counsel · 31 transactions | — | 23.5Kas of Jun 2024 | 63.3K | — | 41.0K |
| Connelly Deirdre PDirector · 3 transactions | — | 22.1K | 22.1K | — | — |
| Ciambrone WilliamEVP · 3 transactions | — | 22.1Kas of Mar 2022 | 23.0K | — | — |
| Mayo StephenDirector · 9 transactions | — | 18.6K | 29.9K | — | 11.2K |
| Gray Mary AnnDirector · 7 transactions | — | 12.4Kas of Mar 2022 | 12.3K | — | — |
| Cumbo AlexanderEVP, Chief Commercial Officer · 34 transactions | — | 12.0K†as of Feb 2020 | 105.2K | — | 96.7K |
| Bonney Michael WDirector · 4 transactions | — | 9.1Kas of Feb 2020 | 7.1K | 2.0K | — |
| Goolsbee William AldenDirector · 7 transactions | — | 8.2Kas of Feb 2016 | 14.8K | — | — |
| Bratica JosephPrincipal Financial Officer · 6 transactions | — | 8.1Kas of Dec 2020 | 3.4K | — | 3.4K |
| Martin John CDirector · 3 transactions | — | 7.9Kas of Mar 2021 | 7.9K | — | — |
| Jacobsen Michael AVP of Finance and PAO · 1 transaction | — | 7.5Kas of Aug 2012 | 7.5K | — | — |
| Hodgman JohnDirector · 8 transactions | — | 6.3Kas of Feb 2015 | 19.4K | — | 5.6K |
| Bowman Jack LDirector · 1 transaction | — | 5.0Kas of May 2007 | — | 5.0K | — |
| Kress Jean-PaulDirector · 2 transactions | — | 2.0Kas of Mar 2017 | 2.0K | — | — |