| Shepley Ruth10% owner · 1 transaction | — | 49.00Mas of Oct 2007 | — | — | — |
| Shkreli MartinFmr Officer Dir 10% Sharehldr · 53 transactions | — | 1.77Mas of Nov 2014 | — | 540.5K | 1.76M |
| Dube Eric MCHIEF EXECUTIVE OFFICER, Director · 68 transactions | — | 432.9K | 1.12M | — | 749.3K |
| Aselage SteveDirector · 73 transactions | — | 347.7K†as of May 2022 | 314.7K | 15.6K | 348.8K |
| Panoff Marc LChief Financial Officer · 2 transactions | — | 221.1Kas of Feb 2014 | 100.0K | 1.1K | — |
| Shih AlvinEVP of Research & Development · 8 transactions | — | 158.3Kas of Sep 2016 | — | — | 71.7K |
| Heerma PeterCHIEF COMMERCIAL OFFICER · 45 transactions | — | 140.7K | 208.6K | — | 76.7K |
| Cline Christopher R.CHIEF FINANCIAL OFFICER · 37 transactions | — | 118.7K | 149.8K | — | 59.9K |
| Rote William E.Chief Research Officer · 79 transactions | — | 115.5K | 281.6K | — | 176.5K |
| Inrig JulaCHIEF MEDICAL OFFICER · 36 transactions | — | 112.8K | 191.4K | — | 78.1K |
| Reed Elizabeth EChief Legal Officer and GC · 100 transactions | — | 105.2K | 334.7K | — | 231.0K |
| Valeur Jensen Margaret EGeneral Counsel · 4 transactions | — | 100.0Kas of Feb 2016 | 150.0K | — | 50.0K |
| Richardson Steven GaryDirector · 4 transactions | — | 99.1Kas of Dec 2014 | 20.0K | 10.1K | — |
| Plotkin HoracioChief Medical Officer · 4 transactions | — | 91.8Kas of Dec 2014 | 100.0K | 2.2K | 10.4K |
| Meckler Jeffrey ADirector · 20 transactions | — | 91.5K | 109.5K | 30.0K | 48.0K |
| Lyons Gary ADirector · 18 transactions | — | 61.5K | 109.5K | — | 48.0K |
| Coughlin TimothyDirector · 13 transactions | — | 56.3K | 58.5K | — | 31.3K |
| Paley JeffreyDirector · 1 transaction | — | 51.7Kas of Aug 2014 | — | — | 20.0K |
| Rosenberg Noah L.Chief Medical Officer · 26 transactions | — | 47.6Kas of Aug 2021 | 62.0K | — | 16.5K |
| Baynes Roy D.Director · 30 transactions | — | 46.0K | 129.0K | — | 87.5K |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER · 47 transactions | — | 42.4K | 211.9K | — | 199.7K |
| Orwin John ADirector · 10 transactions | — | 39.4K | 39.4K | — | — |
| Squarer RonDirector · 10 transactions | — | 39.4K | 39.4K | — | — |
| Clague LauraChief Financial Officer · 51 transactions | — | 35.7Kas of May 2022 | 117.9K | — | 82.2K |
| Poole SandraDirector · 8 transactions | — | 34.0K | 34.0K | — | — |
| Bruhn Suzanne LouiseDirector · 7 transactions | — | 32.8K | 32.8K | — | — |
| Williams Brinkley RuthDirector · 5 transactions | — | 29.8K | 24.5K | — | — |
| Coughlin Timothy PDirector · 5 transactions | — | 29.0Kas of May 2019 | 29.0K | — | — |
| Golding Cornelius EDirector · 5 transactions | — | 29.0Kas of May 2016 | 24.0K | 5.0K | — |
| Kozarich John WDirector · 5 transactions | — | 29.0Kas of May 2019 | 29.0K | — | — |
| McFarlane Neil F.Chief Operating Officer · 12 transactions | — | 27.0Kas of May 2019 | 49.2K | — | 24.5K |
| Brinkley Ruth WilliamsDirector · 1 transaction | — | 5.3Kas of Sep 2021 | 5.3K | — | — |