| Kairouz Habib +9 co-filers10% owner · 8 transactions | — | 8.57M†as of Nov 2006 | — | — | 553.5K |
| Deerfield Management Co +5 co-filersReporting owner · 9 transactions | — | 6.00M†as of Dec 2015 | — | 437.2K | — |
| Care Capital II LLC +3 co-filers10% owner · 18 transactions | — | 4.84M†as of Dec 2006 | — | — | 1.72M |
| Bio One Capital Pte Ltd. +2 co-filers10% owner · 9 transactions | — | 4.43M†as of Nov 2006 | — | — | 715.7K |
| Deerfield Management Co +5 co-filersReporting owner · 15 transactions | — | 4.33M†as of Sep 2016 | — | — | 1.67M |
| Deerfield Management Co +4 co-filersReporting owner · 12 transactions | — | 4.14M†as of Dec 2014 | — | 162.0K | — |
| Barkas Alexander E +5 co-filers10% owner · 4 transactions | — | 3.88M†as of Nov 2006 | — | — | — |
| Tananbaum James BDirector · 9 transactions | — | 3.14M†as of Dec 2006 | — | — | 745.5K |
| Tang Capital Management LLC +2 co-filers10% owner · 15 transactions | — | 2.72Mas of Jan 2010 | — | 2.57M | 950.0K |
| Polymeropoulos Mihael HristosPresident and CEO, Director, Chairman of the Board · 224 transactions | — | 2.70M | 4.82M | 470.0K | 2.27M |
| Blair James C10% owner · 7 transactions | — | 2.00M†as of Dec 2006 | — | — | 12.9K |
| Dovey Brian H10% owner · 7 transactions | — | 2.00M†as of Dec 2006 | — | — | 12.9K |
| More Robert J10% owner · 7 transactions | — | 2.00M†as of Dec 2006 | — | — | 12.9K |
| Schoemaker Kathleen K10% owner · 7 transactions | — | 2.00M†as of Dec 2006 | — | — | 12.9K |
| Treu Jesse I10% owner · 7 transactions | — | 2.00M†as of Dec 2006 | — | — | 12.9K |
| Vitullo Nicole10% owner · 7 transactions | — | 2.00M†as of Dec 2006 | — | — | 12.9K |
| Domain Partners VI, L.P.10% owner · 3 transactions | — | 1.95Mas of Dec 2006 | — | — | — |
| Karabelas Argeris NDirector · 34 transactions | — | 1.95M†as of Mar 2010 | — | — | 3.61M |
| Ramsay David RussFormer Director · 34 transactions | — | 1.95M†as of Mar 2010 | — | — | 3.61M |
| Hockmeyer Wayne TDirector · 1 transaction | — | 1.60Mas of Apr 2006 | — | — | — |
| Medimmune Inc /De10% owner · 1 transaction | — | 1.60Mas of Apr 2006 | — | — | — |
| Birznieks GuntherSVP, Business Development · 30 transactions | — | 494.2K | 564.4K | — | 170.1K |
| Moran Kevin PatrickSVP, CFO & Treasurer · 26 transactions | — | 412.6K† | 497.9K | 2.0K | 122.4K |
| Williams TimothySVP & General Counsel · 29 transactions | — | 377.4K | 563.1K | — | 158.7K |
| Wijkstrom JoakimSVP, Chief Marketing Officer · 20 transactions | — | 333.5K | 433.9K | — | 84.9K |
| Dugan Richard WDirector · 21 transactions | — | 219.1K | 261.2K | — | 42.2K |
| Kelly James PatrickEVP & Chief Financial Officer · 43 transactions | — | 186.9Kas of Mar 2020 | 277.5K | 5.0K | 101.5K |
| Clark William DSr. VP, Chief Business Officer · 88 transactions | — | 168.3Kas of Feb 2010 | 445.6K | 50.0K | 277.3K |
| Reverberi Gian PieroSVP & Chief Commercial Officer · 13 transactions | — | 165.4Kas of Mar 2020 | 130.0K | — | 4.6K |
| Chrousos PhaedraDirector · 9 transactions | — | 164.9K | 167.0K | — | 2.1K |
| Ward Anne SempowskiDirector · 7 transactions | — | 160.7K | 160.7K | — | — |
| Honore TageDirector · 6 transactions | — | 135.1K | 165.1K | — | 30.0K |
| Gulino Richard L.SVP, General Counsel & Sec. · 9 transactions | — | 115.1Kas of Mar 2018 | 100.0K | — | 24.9K |
| Mitchell Stephen RayDirector · 17 transactions | — | 112.8K | 183.8K | — | 45.3K |
| Duncan Charles CliffDirector · 2 transactions | — | 98.7K | 98.7K | — | — |
| Jones Aranthan IIChief Corp. Affairs Officer · 13 transactions | — | 82.0Kas of Sep 2021 | 105.4K | — | 83.4K |
| Watkins ThomasDirector · 14 transactions | — | 69.5Kas of Jun 2022 | 120.0K | — | 56.9K |
| Baroldi PaoloSVP & Chief Medical Officer · 14 transactions | — | 58.2Kas of Jan 2017 | 82.5K | — | 37.6K |
| Repella RobertSVP & Chief Commercial Officer · 8 transactions | — | 44.5Kas of Nov 2013 | 122.5K | — | 107.5K |
| DP VI Associates, L.P.10% owner · 2 transactions | — | 21.1Kas of Dec 2006 | — | — | 12.9K |
| Cola Michael FDirector · 3 transactions | — | 15.0Kas of Jun 2019 | 15.0K | — | — |
| Feeney John JosephSVP & Chief Medical Officer · 23 transactions | — | 12.0Kas of Feb 2012 | 73.9K | — | 67.0K |
| Milano VincentDirector · 2 transactions | — | 10.0Kas of Jun 2018 | 10.0K | — | — |
| Halak Brian KDirector · 1 transaction | — | 7.3Kas of Mar 2010 | — | — | — |
| McGuire Daniel PatrickSVP, GC and Secretary · 1 transaction | — | 6.0K | 80.0K | — | — |
| Bate KennethDirector · 1 transaction | — | 5.0Kas of Jun 2017 | 5.0K | — | — |
| Irish Stephanie RastActing CFO/Treasurer · 5 transactions | — | 2.2Kas of Feb 2010 | 40.0K | — | 37.6K |
| Shallcross Steven ASr. VP, CFO, Treasurer · 40 transactions | — | 1.7Kas of Nov 2007 | 46.3K | — | 46.3K |
| Phadke Deepak ShripadVice President Manufacturing · 2 transactions | — | 0as of Dec 2006 | 4.7K | — | 4.7K |
| Gianchetti Albert W.Sr.VP,Chief Commercial Officer · 1 transaction | — | 0as of Oct 2007 | 3.0K | — | — |