MANE

On August 12, 2026, SR One Fund II Aggregator and AMZL sold an aggregate of 321,749 shares of the Common Stock of the Issuer in a privately negotiated transaction (the "Sale"). In the Sale, SR One Fund II Aggregator sold 217,162 shares of Common Stock and AMZL sold 104,587 shares of Common Stock, in each case at a price of $104.30 per share, for aggregate consideration of approximately $33,558,420. Following the Sale, SR One Fund II Aggregator now holds 1,403,959 shares of Common Stock (the "SR One Fund II Aggregator Shares"), and AMZL now holds 676,160 shares of Common Stock (the "AMZL Shares"). Collectively, the Funds now hold a total of 2,080,119 shares of Common Stock of the Issuer (the "Fund Shares"). Depending on market conditions and other factors, the Funds may dispose of additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries; (d) Any change in the present board of directors or management of the Issuer, including any plans or proposals to change the number or term of directors or to fill any existing vacancies on the board; (e) Any material change in the present capitalization or dividend policy of the Issuer; (f) Any other material change in the Issuer's business or corporate structure; (g) Changes in the Issuer's charter, bylaws or instruments corresponding thereto or other actions which may impede the acquisition of control of the Issuer by any person; (h) Causing a class of securities of the Issuer to be delisted from a national securities exchange or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered national securities association; (i) A class of equity securities of the Issuer becoming eligible for termination of registration pursuant to Section 12(g)(4) of the Securities Exchange Act of 1934; or (j) Any action similar to any of those enumerated above.

On August 12, 2026, SR One Fund II Aggregator and AMZL sold an aggregate of 321,749 shares of the Common Stock of the Issuer in a privately negotiated transaction (the "Sale"). In the Sale, SR One Fund II Aggregator sold 217,162 shares of Common Stock and AMZL sold 104,587 shares of Common Stock, in each case at a price of $104.30 per share, for aggregate consideration of approximately $33,558,420. Following the Sale, SR One Fund II Aggregator now holds 1,403,959 shares of Common Stock (the "SR One Fund II Aggregator Shares"), and AMZL now holds 676,160 shares of Common Stock (the "AMZL Shares"). Collectively, the Funds now hold a total of 2,080,119 shares of Common Stock of the Issuer (the "Fund Shares"). Depending on market conditions and other factors, the Funds may dispose of additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries; (d) Any change in the present board of directors or management of the Issuer, including any plans or proposals to change the number or term of directors or to fill any existing vacancies on the board; (e) Any material change in the present capitalization or dividend policy of the Issuer; (f) Any other material change in the Issuer's business or corporate structure; (g) Changes in the Issuer's charter, bylaws or instruments corresponding thereto or other actions which may impede the acquisition of control of the Issuer by any person; (h) Causing a class of securities of the Issuer to be delisted from a national securities exchange or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered national securities association; (i) A class of equity securities of the Issuer becoming eligible for termination of registration pursuant to Section 12(g)(4) of the Securities Exchange Act of 1934; or (j) Any action similar to any of those enumerated above.

On August 12, 2026, SR One Fund II Aggregator and AMZL sold an aggregate of 321,749 shares of the Common Stock of the Issuer in a privately negotiated transaction (the "Sale"). In the Sale, SR One Fund II Aggregator sold 217,162 shares of Common Stock and AMZL sold 104,587 shares of Common Stock, in each case at a price of $104.30 per share, for aggregate consideration of approximately $33,558,420. Following the Sale, SR One Fund II Aggregator now holds 1,403,959 shares of Common Stock (the "SR One Fund II Aggregator Shares"), and AMZL now holds 676,160 shares of Common Stock (the "AMZL Shares"). Collectively, the Funds now hold a total of 2,080,119 shares of Common Stock of the Issuer (the "Fund Shares"). Depending on market conditions and other factors, the Funds may dispose of additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries; (d) Any change in the present board of directors or management of the Issuer, including any plans or proposals to change the number or term of directors or to fill any existing vacancies on the board; (e) Any material change in the present capitalization or dividend policy of the Issuer; (f) Any other material change in the Issuer's business or corporate structure; (g) Changes in the Issuer's charter, bylaws or instruments corresponding thereto or other actions which may impede the acquisition of control of the Issuer by any person; (h) Causing a class of securities of the Issuer to be delisted from a national securities exchange or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered national securities association; (i) A class of equity securities of the Issuer becoming eligible for termination of registration pursuant to Section 12(g)(4) of the Securities Exchange Act of 1934; or (j) Any action similar to any of those enumerated above.

On August 12, 2026, SR One Fund II Aggregator and AMZL sold an aggregate of 321,749 shares of the Common Stock of the Issuer in a privately negotiated transaction (the "Sale"). In the Sale, SR One Fund II Aggregator sold 217,162 shares of Common Stock and AMZL sold 104,587 shares of Common Stock, in each case at a price of $104.30 per share, for aggregate consideration of approximately $33,558,420. Following the Sale, SR One Fund II Aggregator now holds 1,403,959 shares of Common Stock (the "SR One Fund II Aggregator Shares"), and AMZL now holds 676,160 shares of Common Stock (the "AMZL Shares"). Collectively, the Funds now hold a total of 2,080,119 shares of Common Stock of the Issuer (the "Fund Shares"). Depending on market conditions and other factors, the Funds may dispose of additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries; (d) Any change in the present board of directors or management of the Issuer, including any plans or proposals to change the number or term of directors or to fill any existing vacancies on the board; (e) Any material change in the present capitalization or dividend policy of the Issuer; (f) Any other material change in the Issuer's business or corporate structure; (g) Changes in the Issuer's charter, bylaws or instruments corresponding thereto or other actions which may impede the acquisition of control of the Issuer by any person; (h) Causing a class of securities of the Issuer to be delisted from a national securities exchange or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered national securities association; (i) A class of equity securities of the Issuer becoming eligible for termination of registration pursuant to Section 12(g)(4) of the Securities Exchange Act of 1934; or (j) Any action similar to any of those enumerated above.

On August 12, 2026, SR One Fund II Aggregator and AMZL sold an aggregate of 321,749 shares of the Common Stock of the Issuer in a privately negotiated transaction (the "Sale"). In the Sale, SR One Fund II Aggregator sold 217,162 shares of Common Stock and AMZL sold 104,587 shares of Common Stock, in each case at a price of $104.30 per share, for aggregate consideration of approximately $33,558,420. Following the Sale, SR One Fund II Aggregator now holds 1,403,959 shares of Common Stock (the "SR One Fund II Aggregator Shares"), and AMZL now holds 676,160 shares of Common Stock (the "AMZL Shares"). Collectively, the Funds now hold a total of 2,080,119 shares of Common Stock of the Issuer (the "Fund Shares"). Depending on market conditions and other factors, the Funds may dispose of additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries; (d) Any change in the present board of directors or management of the Issuer, including any plans or proposals to change the number or term of directors or to fill any existing vacancies on the board; (e) Any material change in the present capitalization or dividend policy of the Issuer; (f) Any other material change in the Issuer's business or corporate structure; (g) Changes in the Issuer's charter, bylaws or instruments corresponding thereto or other actions which may impede the acquisition of control of the Issuer by any person; (h) Causing a class of securities of the Issuer to be delisted from a national securities exchange or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered national securities association; (i) A class of equity securities of the Issuer becoming eligible for termination of registration pursuant to Section 12(g)(4) of the Securities Exchange Act of 1934; or (j) Any action similar to any of those enumerated above.

On August 12, 2026, SR One Fund II Aggregator and AMZL sold an aggregate of 321,749 shares of the Common Stock of the Issuer in a privately negotiated transaction (the "Sale"). In the Sale, SR One Fund II Aggregator sold 217,162 shares of Common Stock and AMZL sold 104,587 shares of Common Stock, in each case at a price of $104.30 per share, for aggregate consideration of approximately $33,558,420. Following the Sale, SR One Fund II Aggregator now holds 1,403,959 shares of Common Stock (the "SR One Fund II Aggregator Shares"), and AMZL now holds 676,160 shares of Common Stock (the "AMZL Shares"). Collectively, the Funds now hold a total of 2,080,119 shares of Common Stock of the Issuer (the "Fund Shares"). Depending on market conditions and other factors, the Funds may dispose of additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries; (d) Any change in the present board of directors or management of the Issuer, including any plans or proposals to change the number or term of directors or to fill any existing vacancies on the board; (e) Any material change in the present capitalization or dividend policy of the Issuer; (f) Any other material change in the Issuer's business or corporate structure; (g) Changes in the Issuer's charter, bylaws or instruments corresponding thereto or other actions which may impede the acquisition of control of the Issuer by any person; (h) Causing a class of securities of the Issuer to be delisted from a national securities exchange or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered national securities association; (i) A class of equity securities of the Issuer becoming eligible for termination of registration pursuant to Section 12(g)(4) of the Securities Exchange Act of 1934; or (j) Any action similar to any of those enumerated above.