Rhythm Pharmaceuticals, Inc.
A biopharmaceutical company that makes medicines for rare genetic diseases of severe obesity, marked by insatiable hunger and excess weight gain. Its marketed drug, IMCIVREE (setmelanotide), is a precision medicine that restores a signaling pathway in the brain controlling hunger and fullness for patients with conditions such as Bardet-Biedl syndrome and POMC deficiency. Founded in 2008 in Boston, the company's name echoes the body's internal rhythm of hunger and metabolism its medicines aim to reset.
| Holder | Schedule | % of class | Shares | Filed |
|---|---|---|---|---|
| Perceptive Advisors LLC | 13G/APassive | 5.1% | 3.52M | May 15, 2026 |
| Joseph Edelman | 13G/APassive | 5.1% | 3.52M | May 15, 2026 |
| Perceptive Life Sciences Master Fund, Ltd. | 13G/APassive | 4.1% | 2.79M | May 15, 2026 |
| Perceptive Capital Solutions Holdings LP | 13G/APassive | 1.1% | 729.2K | May 15, 2026 |
| Vanguard Capital Management | 13GPassive | 5.02% | 3.43M | Apr 30, 2026 |
| The Vanguard Group | 13G/APassive | 0% | 0 | Mar 27, 2026 |
| RA Capital Management, L.P. | 13G/APassive | 9.9% | 6.67M | Feb 17, 2026 |
| Peter Kolchinsky | 13G/APassive | 9.9% | 6.67M | Feb 17, 2026 |
| Rajeev Shah | 13G/APassive | 9.9% | 6.67M | Feb 17, 2026 |
| RA Capital Healthcare Fund, L.P. | 13G/APassive | 9.9% | 6.67M | Feb 17, 2026 |