You should read the following discussion and analysis of our financial condition and results of operations together with the unaudited condensed consolidated financial statements and related notes and the other financial information appearing elsewhere in this report, as well as the other financial information we file with the SEC from time to time. Some of the information contained in this discussion and analysis or set forth elsewhere in this report, including information with respect to our plans and strategy for our business and related financing, includes forward-looking statements that involve risks and uncertainties relating to our future plans, objectives, expectations, intentions and financial performance and the assumptions that underlie these statements. As a result of many factors, including those factors set forth in the “Risk Factors” section of this report, our actual results could differ materially from the results described in or implied by the forward-looking statements contained in the following discussion and analysis. Overview We are advancing the field of immune medicine by harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature’s most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our immune medicine platform applies our proprietary technologies to read the diverse genetic code of a patient’s immune system and understand precisely how the immune system detects and treats disease in that patient. We capture these insights in our dynamic clinical immunomics database and related antigen annotations, which are underpinned by computational biology and machine learning, and use them to develop and commercialize clinical products and services that can be tailored to the needs of individual patients. Our existing and future commercial products and services are aligned to two business areas which we refer to as MRD and Immune Medicine. Our current product and service offerings in MRD related to the MRD market are our clonoSEQ clinical diagnostic test, offered to clinicians, and our clonoSEQ or MRD assay, offered to biopharmaceutical partners to advance drug development efforts. Our first clinical diagnostic product, clonoSEQ, is the first test authorized by the Food and Drug Administration for the detection and monitoring of MRD in patients with multiple myeloma, B cell acute lymphoblastic leukemia and chronic lymphocytic leukemia, and is also available as a CLIA-validated laboratory developed test for patients with other lymphoid cancers, including diffuse large B cell lymphoma and mantle cell lymphoma (“MCL”). In the fourth quarter of 2024, we obtained Medicare coverage for MCL and initiated promotional efforts in MCL. We also obtained a new Medicare Clinical Laboratory Fee Schedule rate of $2,007 per test for clonoSEQ and MolDX separately updated the clonoSEQ episode pricing to $8,029 for all covered indications. This represented a 17% increase from the previous episode price. In April 2025, Palmetto GBA expanded coverage of clonoSEQ to include single time point testing to monitor for recurrence in patients with a history of MCL. This expanded coverage is in addition to the existing Medicare episode payment structure for clonoSEQ. With the use of clonoSEQ, we are transforming how lymphoid cancers are treated by working with providers, pharmaceutical partners and payors. In an effort to enable easier test ordering, we have integrated our clonoSEQ test into electronic medical record systems, including Epic Systems Corporation’s Aura and Flatiron Health, Inc.’s OncoEMR®, of numerous accounts. Immune Medicine leverages our proprietary ability to sequence, map, pair and characterize TCRs and B cell receptors at scale to drive opportunities in cancer and autoimmune disorders. Our capabilities enable us to offer an expanding suite of solutions including immune receptor sequencing, licensing of our proprietary data, TCR-antigen prediction models and our target discovery capabilities. We are applying artificial intelligence and machine learning models to map at scale TCR sequences to the diseases they bind to enable commercial offerings and our own product research initiatives. We recognized revenue of $71.6 million and $58.9 million for the three months ended June 30, 2026 and 2025, respectively, and $142.4 million and $111.3 million for the six months ended June 30, 2026 and 2025, respectively. Net loss attributable to Adaptive Biotechnologies Corporation was $39.8 million and $25.6 million for the three months ended June 30, 2026 and 2025, respectively, and $59.8 million and $55.5 million for the six months ended June 30, 2026 and 2025, respectively. We have funded our operations to date principally from the sale of convertible preferred stock and common stock, including the sale of common stock in our initial public offering and follow-on offering, revenue, proceeds received from the revenue interest purchase agreement entered into in September 2022 (the “Purchase Agreement”) and proceeds received from the June 2026 issuance of 0% convertible senior notes due 2031 (the “Notes”). As of June 30, 2026 and December 31, 2025, we had cash, cash equivalents and marketable securities of $371.7 million and $240.2 million, respectively. These balances include $15.1 million and $13.1 million of cash and cash equivalents held by Digital Biotechnologies, Inc., respectively. 25 Adaptive Biotechnologies Corporation Recent Developments In June 2026, we announced our intention to pursue a separation of our Immune Medicine and MRD businesses, with the intent to identify our preferred path of separation by year-end 2026. Additionally, in July 2026, we decided to wind down our research-use-only pharma services offering for T-cell receptor sequencing, or Adaptive Immunosequencing. The change will enable the Immune Medicine business to focus on our proprietary TCR-antigen dataset, our artificial intelligence and machine learning digital models and our target discovery platform for autoimmune disease. Also in June 2026, we issued $345.0 million in aggregate principal amount of Notes and used $25.6 million of the proceeds to enter into privately negotiated capped call transactions. The capped call transactions are generally expected to reduce the potential dilution to our common stock upon any conversion of the Notes and/or offset any potential cash payments we are required to make in excess of the principal amount of converted Notes, as the case may be, with such reduction and/or offset subject to a cap. We also used $156.9 million of the proceeds to extinguish our revenue interest liability under the Purchase Agreement and $25.0 million to repurchase 1,451,800 shares of our common stock. Components of Results of Operations Revenue We derive revenue by providing diagnostic and research services in our MRD and Immune Medicine business areas. Our MRD revenue consists of revenue generated from (1) providing our clonoSEQ report to clinical customers; (2) providing MRD sample testing services to biopharmaceutical customers and certain academic institutions, including investigator-led clinical trials; and (3) providing our clonoSEQ report or results to certain international laboratory sites through technology transfers. We disclose our clonoSEQ test volume, which includes the number of clonoSEQ reports and results we have provided to ordering physicians in the United States (“U.S.”) and international technology transfer sites. These volumes do not include sample results from our biopharmaceutical customers or academic institutions utilizing our MRD services. Our Immune Medicine revenue consists of revenue generated from (1) providing sample testing services for our commercial research product, Adaptive Immunosequencing; (2) data licensing and target discovery services; and (3) for periods prior to October 1, 2025, our former collaboration with Genentech, Inc. (“Genentech”) under the worldwide collaboration and license agreement with Genentech (the “Genentech Agreement”). For our clinical customers, we primarily derive revenue from providing our clonoSEQ report to ordering physicians. We bill commercial, government and medical institution payors based on reports delivered to ordering physicians. Amounts paid for clonoSEQ by commercial, government and medical institution payors vary based on respective reimbursement rates and patient responsibilities, which may differ from our targeted list price. We recognize clinical revenue by evaluating customer payment history, contracted reimbursement rates, if applicable, and other adjustments to estimate the amount of revenue that is collectible. For our clonoSEQ coverage under Medicare, we bill an episode of treatment when we deliver the first eligible test report. This billing contemplates all necessary tests required during a patient’s treatment cycle, which is currently estimated at approximately four tests per patient, including the initial sequence identification test. Revenue recognition commences at the time the initial billable test report is delivered and is based upon cumulative tests delivered to date. Any unrecognized revenue from the initial billable test is recorded as deferred revenue and recognized either as we deliver our estimate of the remaining tests in a patient’s treatment cycle or when the likelihood becomes remote that a patient will receive additional testing. In certain cases, we continue to provide services and incur costs for patients who exceed our number of estimated tests. For our research customers, which include biopharmaceutical customers and academic institutions for both our MRD and Adaptive Immunosequencing services, delivery of the respective test results may include some level of professional support and analysis. Terms with biopharmaceutical customers generally include non-refundable payments made in advance of services (“upfront payments”), which we record as deferred revenue. For all research customers, we recognize revenue as we deliver sequencing results. From time to time, we offer discounts in order to gain rights and access to certain datasets. Revenue is recognized net of these discounts and costs associated with these services are reflected in cost of revenue. In periods where our sample estimates are reduced or a customer project is cancelled and, in either case, we have remaining related deferred revenue, we recognize revenue using a cumulative catch-up approach based on the proportion of samples delivered to date relative to the total samples expected to be delivered. Certain of our MRD revenue arrangements with biopharmaceutical customers include cash consideration from the achievement of regulatory milestones of the respective biopharmaceutical customers’ therapeutics. Such revenue is constrained from recognition until it becomes probable that such milestone will be achieved. Under certain agreements with our biopharmaceutical customers who seek access to our platform to support their therapeutic development activities, revenues are generated from research and development support services that we provide or have developed. These agreements have included non-refundable upfront payments. Revenue recognized from these activities include revenue recognized from the former Genentech Agreement and a data licensing agreement. 26 Adaptive Biotechnologies Corporation For our data licensing agreement, we provide non‑exclusive licenses to specified TCR dataset tranches. We identified one performance obligation: the delivery of the respective TCR dataset tranche. We recognize revenue upon delivery of such licensed data. We also have the right to receive additional consideration upon the renewal or exercise of additional TCR dataset tranche licenses. These do not represent material rights, and as such, will be accounted for when and if exercised. For our target discovery agreement, we received an initial upfront payment and rights to additional consideration upon the delivery of completed disease-specific TCRs pursuant to a research plan. We identified two distinct performance obligations: (1) to provide Adaptive Immunosequencing services for customer provided specimens; and (2) the delivery of the disease-specific TCRs with the associated license rights. The consideration allocated to each of the respective performance obligations is recognized as revenue upon the delivery of the respective datasets. If the customer elects to further develop therapeutics, we may be eligible to receive additional development, commercial and sales milestone payments that could total up to $877.5 million. All such development, commercial and sales‑based milestone payments are fully constrained until the underlying triggering events occur. The customer is solely responsible for any subsequent development costs following the conclusion of the research plan. We expect our MRD revenue to increase in both the short term and long term as we continue to increase our MRD clinical testing volume through enhanced penetration in our existing covered patient populations, expand into new patient populations and optimize payor coverage. Our MRD revenue may fluctuate period to period due to the uncertain timing of receipt of our biopharmaceutical customer samples, which may cause uncertainty in the delivery of our products and services, the recognition of milestones related to regulatory approvals of our biopharmaceutical customers’ therapeutics and changes in estimates of our clinical revenue reimbursement rates. We expect our Immune Medicine revenue to decrease in the short term as we wind down Adaptive Immunosequencing services over the second half of 2026 and focus on target discovery business development efforts. Following the wind down of Adaptive Immunosequencing services, our Immune Medicine revenue may fluctuate from period to period due to the potential recognition of milestones under our target discovery agreement and any future licensing agreements. Cost of Revenue Cost of revenue includes the cost of materials, personnel-related expenses (including salaries, benefits and share-based compensation), shipping and handling expenses, equipment costs, allocated facility costs associated with processing samples and professional support costs related to our service revenue activities. Allocated facility costs include depreciation of laboratory equipment, as well as allocated facility occupancy and information technology costs. Costs associated with processing samples are recorded as expense, regardless of the timing of revenue recognition. As such, cost of revenue and related volume does not always trend in the same direction as revenue recognition and related volume. Additionally, costs to support the Genentech Agreement were a component of our research and development expenses. We expect cost of revenue to moderately increase in the short term and to increase in absolute dollars in the long term as we grow our sample testing volume, but the cost per sample to decrease over the long term due to the efficiencies we may gain as assay volume increases from improved utilization of our laboratory capacity, automation and other value engineering initiatives. If our sample volume throughput is reduced, cost of revenue as a percentage of total revenue may be adversely impacted due to fixed overhead costs. Research and Development Expenses Research and development expenses consist of laboratory materials costs, personnel-related expenses (including salaries, benefits and share-based compensation), equipment costs, allocated facility and information technology costs and contract service expenses. Research and development activities support further development and refinement of existing assays and products, discovery of new technologies and investments in our immune medicine platform. We also include in research and development expenses the costs associated with software development of applications to support future commercial opportunities, as well as development activities to support laboratory scaling and workflow. We are currently conducting research and development activities for several products and services and we typically use our laboratory materials, personnel, facilities, information technology and other development resources across multiple development programs. Additionally, certain of these research and development activities benefit more than one of our product opportunities. The costs to support the Genentech Agreement were a component of our research and development expenses. Additionally, a component of our research and development expenses are costs supporting clinical and analytical validations to obtain regulatory approval for future clinical products and services. Some of these activities have generated and may in the future generate revenue. We expect research and development expenses to moderately decrease in the short term and to decrease as a percentage of revenue in the long term, although the percentage may fluctuate from period to period due to the timing and extent of our development and commercialization efforts. 27 Adaptive Biotechnologies Corporation Sales and Marketing Expenses Sales and marketing expenses include personnel-related expenses (including salaries, benefits and share-based compensation) for commercial sales, product and account management, marketing, reimbursement, medical education and business development personnel that support commercialization of our platform products. In addition, these expenses include external costs such as advertising expenses, customer education and promotional expenses, market analysis expenses, conference fees, travel expenses and allocated facility and information technology costs. We expect sales and marketing expenses to moderately increase in the short term. In the long term, we expect sales and marketing expenses to increase in absolute dollars as we increase marketing activities to drive awareness and adoption of our products and services. However, we expect sales and marketing expenses to decrease as a percentage of revenue in the long term, subject to fluctuations from period to period due to the timing and magnitude of these expenses. General and Administrative Expenses General and administrative expenses include personnel-related expenses (including salaries, benefits and share-based compensation) for our personnel in executive, legal, finance and accounting, human resources and other administrative functions, including third-party clinical billing services. In addition, these expenses include insurance costs, external legal costs, accounting and tax service expenses, consulting fees and allocated facility and information technology costs. We expect general and administrative expenses to moderately increase in the short term and to decrease as a percentage of revenue in the long term. Interest Expense Interest expense includes costs associated with our now settled revenue interest liability and the noncash interest costs associated with the full amortization of deferred issuance costs related to the Purchase Agreement, as well as the amortization of deferred costs related to issuance of the Notes. We impute interest expense using the effective interest method. Loss on Revenue Interest Liability Extinguishment Loss on revenue interest liability extinguishment represents the loss recognized in connection with our early settlement of the revenue interest liability under the Purchase Agreement. 28 Adaptive Biotechnologies Corporation Statements of Operations Data and Other Financial and Operating Data The following table sets forth our statements of operations data and other financial and operating data for the periods presented (in thousands, except share and per share amounts): Three Months Ended June 30, Six Months Ended June 30, 2026 2025 2026 2025 Statements of Operations Data: Revenue $ 71,553 $ 58,879 $ 142,427 $ 111,322 Operating expenses Cost of revenue 20,165 17,999 38,873 34,978 Research and development 19,153 24,134 42,776 48,337 Sales and marketing 26,414 23,573 52,760 46,620 General and administrative 21,168 17,786 42,152 35,185 Amortization of intangible assets 423 423 842 842 Total operating expenses 87,323 83,915 177,403 165,962 Loss from operations (15,770 ) (25,036 ) (34,976 ) (54,640 ) Interest and other income, net 2,256 2,391 4,336 5,070 Interest expense (2,694 ) (2,948 ) (5,583 ) (5,853 ) Loss on revenue interest liability extinguishment (23,733 ) — (23,733 ) — Net loss (39,941 ) (25,593 ) (59,956 ) (55,423 ) Add: Net loss (income) attributable to noncontrolling interest 153 (21 ) 135 (43 ) Net loss attributable to Adaptive Biotechnologies Corporation $ (39,788 ) $ (25,614 ) $ (59,821 ) $ (55,466 ) Net loss per share attributable to Adaptive Biotechnologies Corporation common shareholders, basic and diluted $ (0.25 ) $ (0.17 ) $ (0.38 ) $ (0.37 ) Weighted-average shares used in computing net loss per share attributable to Adaptive Biotechnologies Corporation common shareholders, basic and diluted 159,855,257 152,082,284 157,700,126 150,646,632 Other Financial and Operating Data: Adjusted EBITDA(1) $ (726 ) $ (7,196 ) $ (3,195 ) $ (19,944 ) (1) Adjusted EBITDA is a non-GAAP financial measure that we define as net loss attributable to Adaptive Biotechnologies Corporation adjusted for interest and other income, net, interest expense, income tax (expense) benefit, depreciation and amortization expense, impairment costs for long-lived assets, restructuring expense, share-based compensation expense and revenue interest liability extinguishment loss. See “Adjusted EBITDA” below for a reconciliation between Adjusted EBITDA and net loss attributable to Adaptive Biotechnologies Corporation, the most directly comparable GAAP financial measure, and a discussion about the limitations of Adjusted EBITDA. Comparison of the Three Months Ended June 30, 2026 and 2025 Revenue Three Months Ended June 30, Change Percent of Revenue (in thousands, except percentages) 2026 2025 $ % 2026 2025 MRD revenue Service revenue $ 66,168 $ 44,438 $ 21,730 49 % Regulatory milestone revenue — 5,500 (5,500 ) (100 ) Total MRD revenue 66,168 49,938 16,230 33 92 % 85 % Immune Medicine revenue Service and licensing revenue 5,385 5,001 384 8 Collaboration revenue — 3,940 (3,940 ) (100 ) Total Immune Medicine revenue 5,385 8,941 (3,556 ) (40 ) 8 % 15 % Total revenue $ 71,553 $ 58,879 $ 12,674 22 100 % 100 % 29 Adaptive Biotechnologies Corporation The $16.2 million increase in MRD revenue was primarily due to a $17.0 million increase in revenue generated from providing clonoSEQ to clinical customers and a $4.5 million increase in revenue generated from providing MRD sample testing services to biopharmaceutical customers. These increases were partially offset by a $5.5 million decrease in revenue recognized upon the achievement of regulatory milestones by our biopharmaceutical customers. Our clonoSEQ test volume increased by 43% to 36,111 tests delivered in the three months ended June 30, 2026 from 25,321 tests delivered in the three months ended June 30, 2025. The $3.6 million decrease in Immune Medicine revenue was primarily due to a $3.9 million decrease in revenue generated from the Genentech Agreement, resulting from the termination of the Genentech Agreement in August 2025, partially offset by a $0.4 million increase in revenue generated from our biopharmaceutical and academic customers. Cost of Revenue Three Months Ended June 30, Change Percent of Revenue (in thousands, except percentages) 2026 2025 $ % 2026 2025 Cost of revenue $ 20,165 $ 17,999 $ 2,166 12 % 28 % 31 % The $2.2 million increase in cost of revenue was primarily attributable to a $1.1 million increase in labor and overhead costs and a $0.8 million increase in shipping and handling expenses. Research and Development Three Months Ended June 30, Change Percent of Revenue (in thousands, except percentages) 2026 2025 $ % 2026 2025 Research and development $ 19,153 $ 24,134 $ (4,981 ) (21)% 27 % 41 % The following table presents disaggregated research and development expenses by cost classification for the periods presented: Three Months Ended June 30, (in thousands) 2026 2025 Change Research and development materials and allocated production laboratory expenses $ 2,799 $ 4,058 $ (1,259 ) Personnel expenses 12,114 14,281 (2,167 ) Allocable facilities and information technology expenses 1,345 1,799 (454 ) Software and cloud services expenses 2,124 1,365 759 Depreciation and other expenses 771 2,631 (1,860 ) Total $ 19,153 $ 24,134 $ (4,981 ) The $5.0 million decrease in research and development expenses was primarily attributable to a $2.2 million decrease in personnel costs, a $1.9 million decrease in depreciation and other expenses, a $1.3 million decrease in laboratory materials and allocated production laboratory expenses, which was driven primarily by decreased investments in drug discovery and clonoSEQ efforts, and a $0.5 million decrease in allocable facility expenses. These decreases were partially offset by a $0.8 million increase in software and cloud services expenses. Sales and Marketing Three Months Ended June 30, Change Percent of Revenue (in thousands, except percentages) 2026 2025 $ % 2026 2025 Sales and marketing $ 26,414 $ 23,573 $ 2,841 12 % 37 % 40 % The $2.8 million increase in sales and marketing expenses was primarily attributable to a $1.3 million increase in personnel costs, a $0.7 million increase in computer and software expenses, a $0.4 million increase in consulting costs and a $0.3 million increase in travel and customer event related expenses. 30 Adaptive Biotechnologies Corporation General and Administrative Three Months Ended June 30, Change Percent of Revenue (in thousands, except percentages) 2026 2025 $ % 2026 2025 General and administrative $ 21,168 $ 17,786 $ 3,382 19 % 30 % 30 % The $3.4 million increase in general and administrative expenses was primarily attributable to a $1.3 million increase in legal expenses, $0.8 million increase in third-party billing service fees, a $0.5 million increase in computer and software expenses and a $0.4 million increase in personnel costs. Interest and Other Income, Net Three Months Ended June 30, Change (in thousands, except percentages) 2026 2025 $ % Interest and other income, net $ 2,256 $ 2,391 $ (135 ) (6)% The $0.1 million decrease in interest and other income, net was primarily attributable to a nominal decrease in net interest income and investment amortization. Interest Expense Three Months Ended June 30, Change (in thousands, except percentages) 2026 2025 $ % Interest expense $ (2,694 ) $ (2,948 ) $ 254 (9)% The $0.3 million decrease in interest expense was primarily attributable to the early settlement of our revenue interest liability under the Purchase Agreement. Loss on Revenue Interest Liability Extinguishment Three Months Ended June 30, Change (in thousands, except percentages) 2026 2025 $ % Loss on revenue interest liability extinguishment $ (23,733 ) $ — $ (23,733 ) * * Not applicable The $23.7 million increase in loss on revenue interest liability extinguishment represents the loss incurred in June 2026 in connection with our early settlement of the revenue interest liability under the Purchase Agreement. 31 Adaptive Biotechnologies Corporation Segment Adjusted EBITDA Three Months Ended June 30, Change (in thousands, except percentages) 2026 2025(1) $ % MRD Adjusted EBITDA(2) $ 9,116 $ 1,912 $ 7,204 377 % Immune Medicine Adjusted EBITDA(2) (6,269 ) (5,721 ) (548 ) 10 (1) Costs related to Digital Biotechnologies, Inc. are no longer included as Immune Medicine costs and have been reclassified to our unallocated corporate category. (2)Adjusted EBITDA is a non-GAAP financial measure. See “Adjusted EBITDA” below for an explanation of how it is calculated and used by management. Adjusted EBITDA related to our unallocated corporate category is included in the calculation of consolidated Adjusted EBITDA but not shown above in the breakout of segment Adjusted EBITDA. The $7.2 million improvement in MRD Adjusted EBITDA was primarily attributable to a $16.2 million increase in MRD revenue, partially offset by a $9.0 million increase in operating expenses, excluding segment non-cash and restructuring expenses. The increase in these operating expenses was primarily due to a $3.4 million increase in general and administrative expenses driven largely by increased legal expenses, third-party billing service fees and computer and software expenses, a $2.8 million increase in sales and marketing expenses driven primarily by increased market access and personnel expenses and a $2.5 million increase in cost of revenue expenses driven largely by increased testing volumes. The $0.5 million increase in Immune Medicine Adjusted EBITDA deficit was primarily attributable to a $3.6 million decrease in Immune Medicine revenue, resulting largely from the termination of the Genentech Agreement in August 2025, partially offset by a $3.1 million decrease in operating expenses, excluding segment non-cash and restructuring expenses. The decrease in these operating expenses was primarily due to a decrease in research and development expenses driven largely by reduced personnel and laboratory materials costs. Comparison of the Six Months Ended June 30, 2026 and 2025 Revenue Six Months Ended June 30, Change Percent of Revenue (in thousands, except percentages) 2026 2025 $ % 2026 2025 MRD revenue Service revenue $ 124,261 $ 83,659 $ 40,602 49 % Regulatory milestone revenue 9,000 10,000 (1,000 ) (10 ) Total MRD revenue 133,261 93,659 39,602 42 94 % 84 % Immune Medicine revenue Service and licensing revenue 9,166 10,123 (957 ) (9 ) Collaboration revenue — 7,540 (7,540 ) (100 ) Total Immune Medicine revenue 9,166 17,663 (8,497 ) (48 ) 6 % 16 % Total revenue $ 142,427 $ 111,322 $ 31,105 28 100 % 100 % The $39.6 million increase in MRD revenue was primarily due to a $32.9 million increase in revenue generated from providing clonoSEQ to clinical customers and an $8.0 million increase in revenue generated from providing MRD sample testing services to biopharmaceutical customers. These increases were partially offset by a $1.0 million decrease in revenue recognized upon the achievement of regulatory milestones by our biopharmaceutical customers and a $0.6 million decrease in revenue generated from providing MRD sample testing services to investigator-led clinical trials. Our clonoSEQ test volume increased by 42% to 68,706 delivered in the six months ended June 30, 2026 from 48,438 tests delivered in the six months ended June 30, 2025. The $8.5 million decrease in Immune Medicine revenue was primarily due to a $7.5 million decrease in revenue generated from the Genentech Agreement, resulting from the termination of the Genentech Agreement in August 2025, and a $1.0 million decrease in revenue generated from our biopharmaceutical and academic customers. Cost of Revenue Six Months Ended June 30, Change Percent of Revenue (in thousands, except percentages) 2026 2025 $ % 2026 2025 Cost of revenue $ 38,873 $ 34,978 $ 3,895 11 % 27 % 31 % 32 Adaptive Biotechnologies Corporation The $3.9 million increase in cost of revenue was primarily attributable to a $1.8 million increase in labor and overhead costs, a $1.7 million increase in shipping and handling expenses and a $0.2 million increase in cost of materials. Research and Development Six Months Ended June 30, Change Percent of Revenue (in thousands, except percentages) 2026 2025 $ % 2026 2025 Research and development $ 42,776 $ 48,337 $ (5,561 ) (12)% 30 % 43 % The following table presents disaggregated research and development expenses by cost classification for the periods presented: Six Months Ended June 30, (in thousands) 2026 2025 Change Research and development materials and allocated production laboratory expenses $ 5,828 $ 7,702 $ (1,874 ) Personnel expenses 27,135 28,865 (1,730 ) Allocable facilities and information technology expenses 3,205 3,744 (539 ) Software and cloud services expenses 4,096 2,687 1,409 Depreciation and other expenses 2,512 5,339 (2,827 ) Total $ 42,776 $ 48,337 $ (5,561 ) The $5.6 million decrease in research and development expenses was primarily attributable to a $2.8 million decrease in depreciation and other expenses, a $1.9 million decrease in laboratory materials and allocated production laboratory expenses, which was driven primarily by decreased investments in clonoSEQ and drug discovery efforts, a $1.7 million decrease in personnel costs and a $0.5 million decrease in allocable facility expenses. These decreases were partially offset by a $1.4 million increase in software and cloud services expenses. Sales and Marketing Six Months Ended June 30, Change Percent of Revenue (in thousands, except percentages) 2026 2025 $ % 2026 2025 Sales and marketing $ 52,760 $ 46,620 $ 6,140 13 % 37 % 42 % The $6.1 million increase in sales and marketing expenses was primarily attributable to a $3.1 million increase in personnel costs, a $1.1 million increase in travel and customer event related expenses, a $1.1 million increase in computer and software expenses and a $0.5 million increase in consulting costs. General and Administrative Six Months Ended June 30, Change Percent of Revenue (in thousands, except percentages) 2026 2025 $ % 2026 2025 General and administrative $ 42,152 $ 35,185 $ 6,967 20 % 30 % 32 % The $7.0 million increase in general and administrative expenses was primarily attributable to a $2.1 million increase in personnel costs, a $1.7 million increase in third-party billing service fees, a $1.6 million increase in legal expenses and a $1.5 million increase in computer and software expenses. Interest and Other Income, Net Six Months Ended June 30, Change (in thousands, except percentages) 2026 2025 $ % Interest and other income, net $ 4,336 $ 5,070 $ (734 ) (14)% The $0.7 million decrease in interest and other income, net was primarily attributable to a decrease in net interest income and investment amortization driven by decreased holdings of and interest rates pertaining to our cash, cash equivalents and marketable securities. 33 Adaptive Biotechnologies Corporation Interest Expense Six Months Ended June 30, Change (in thousands, except percentages) 2026 2025 $ % Interest expense $ (5,583 ) $ (5,853 ) $ 270 (5)% The $0.3 million decrease in interest expense was primarily attributable to the early settlement of our revenue interest liability under the Purchase Agreement. Loss on Revenue Interest Liability Extinguishment Six Months Ended June 30, Change (in thousands, except percentages) 2026 2025 $ % Loss on revenue interest liability extinguishment $ (23,733 ) $ — $ (23,733 ) * * Not applicable The $23.7 million increase in loss on revenue interest liability extinguishment represents the loss incurred in June 2026 in connection with our early settlement of the revenue interest liability under the Purchase Agreement. Segment Adjusted EBITDA Six Months Ended June 30, Change (in thousands, except percentages) 2026 2025(1) $ % MRD Adjusted EBITDA(2) $ 21,254 $ (2,199 ) $ 23,453 *% Immune Medicine Adjusted EBITDA(2) (16,629 ) (10,827 ) (5,802 ) 54 * Not meaningful, as the comparison reflects a change from negative Adjusted EBITDA to positive Adjusted EBITDA. (1) Costs related to Digital Biotechnologies, Inc. are no longer included as Immune Medicine costs and have been reclassified to our unallocated corporate category. (2)Adjusted EBITDA is a non-GAAP financial measure. See “Adjusted EBITDA” below for an explanation of how it is calculated and used by management. Adjusted EBITDA related to our unallocated corporate category is included in the calculation of consolidated Adjusted EBITDA but not shown above in the breakout of segment Adjusted EBITDA. The $23.5 million improvement in MRD Adjusted EBITDA was primarily attributable to a $39.6 million increase in MRD revenue, partially offset by a $16.1 million increase in operating expenses, excluding segment non-cash and restructuring expenses. The increase in these operating expenses was primarily due to a $5.9 million increase in sales and marketing expenses driven primarily by increased market access and personnel expenses, a $5.8 million increase in general and administrative expenses driven largely by increased legal expenses, third-party billing service fees and computer and software expenses and a $3.9 million increase in cost of revenue expenses driven largely by increased testing volumes. The $5.8 million increase in Immune Medicine Adjusted EBITDA deficit was primarily attributable to an $8.5 million decrease in Immune Medicine revenue, resulting largely from the termination of the Genentech Agreement in August 2025, partially offset by a $2.7 million decrease in operating expenses, excluding segment non-cash and restructuring expenses. The decrease in these operating expenses was primarily due to a decrease in research and development expenses driven largely by reduced personnel and laboratory materials costs. Adjusted EBITDA Adjusted EBITDA is a non-GAAP financial measure that we define as net loss attributable to Adaptive Biotechnologies Corporation adjusted for interest and other income, net, interest expense, income tax (expense) benefit, depreciation and amortization expense, impairment costs for long-lived assets, restructuring expense, share-based compensation expense and revenue interest liability extinguishment loss. We define our segment Adjusted EBITDA in the same way to the extent the net loss attributable to Adaptive Biotechnologies Corporation and adjustments are allocable to each segment. See Note 14, Segment Information of the accompanying notes to the unaudited condensed consolidated financial statements included elsewhere in this report for more information regarding segment Adjusted EBITDA. Management uses Adjusted EBITDA, including segment Adjusted EBITDA, to evaluate the financial performance of our business and segments and to evaluate the effectiveness of our strategies. We present these figures because we believe they are frequently used by analysts, investors and other interested parties to evaluate companies in our industry and they facilitate comparisons on a consistent basis across reporting periods. Further, we believe it is helpful in highlighting trends in our operating results because it excludes items that are not indicative of our core operating performance. 34 Adaptive Biotechnologies Corporation Adjusted EBITDA, including segment Adjusted EBITDA, has limitations as an analytical tool and you should not consider it in isolation or as a substitute for analysis of our results as reported under GAAP. We may in the future incur expenses similar to the adjustments we make. In particular, we expect to incur meaningful share-based compensation expense in the future. Other limitations include that Adjusted EBITDA, including segment Adjusted EBITDA, does not reflect: •all expenditures or future requirements for capital expenditures or contractual commitments; •changes in our working capital needs; •interest income and interest expense, which is an ongoing element of our costs to operate; •income tax (expense) benefit, which may be a necessary element of our costs and ability to operate; •the costs of replacing the assets being depreciated and amortized, which will often have to be replaced in the future; •the noncash component of employee compensation expense; •long-lived assets impairment costs; and •the impact of earnings or charges resulting from matters we consider not to be reflective, on a recurring basis, of our ongoing operations, such as our restructuring activities, reductions in workforce and our revenue interest liability extinguishment loss. In addition, Adjusted EBITDA, including segment Adjusted EBITDA, may not be comparable to similarly titled measures used by other companies in our industry or across different industries. The following is a reconciliation of net loss attributable to Adaptive Biotechnologies Corporation, the most directly comparable GAAP financial measure, to Adjusted EBITDA for the periods presented (in thousands): Three Months Ended June 30, Six Months Ended June 30, 2026 2025 2026 2025 Net loss attributable to Adaptive Biotechnologies Corporation $ (39,788 ) $ (25,614 ) $ (59,821 ) $ (55,466 ) Interest and other income, net (2,256 ) (2,391 ) (4,336 ) (5,070 ) Interest expense(1) 2,694 2,948 5,583 5,853 Depreciation and amortization expense 3,695 4,502 7,532 9,233 Impairment of long-lived assets(2) — — 347 — Restructuring expense(2) 77 — 720 — Share-based compensation expense(3) 11,119 13,359 23,047 25,506 Loss on revenue interest liability extinguishment(4) 23,733 — 23,733 — Adjusted EBITDA $ (726 ) $ (7,196 ) $ (3,195 ) $ (19,944 ) (1) Represents costs associated with our now settled revenue interest liability and the noncash interest costs associated with the full amortization of deferred issuance costs related to the Purchase Agreement, as well as the amortization of deferred costs related to issuance of the Notes. See Note 9, Revenue Interest Purchase Agreement and Note 8, Convertible Senior Notes and Capped Call Transactions of the accompanying notes to the unaudited condensed consolidated financial statements included elsewhere in this report for details on interest expense. (2) Represents expenses recognized in conjunction with a restructuring that primarily impacted research and development activities. (3) Represents share-based compensation expense related to various awards. See Note 12, Equity Incentive Plans of the accompanying notes to the unaudited condensed consolidated financial statements included elsewhere in this report for details on our share-based compensation expense. (4) Represents the loss recognized in connection with our early settlement of the Purchase Agreement. Liquidity and Capital Resources We have incurred losses since inception, apart from the three month period ended September 30, 2025, and have incurred negative cash flows from operations since inception through June 30, 2026, with the exception of certain 2019 periods for which we had positive cash flows from operations. As of June 30, 2026, we had an accumulated deficit of $1.4 billion. 35 Adaptive Biotechnologies Corporation We have funded our operations to date principally from the sale of convertible preferred stock and common stock, revenue, proceeds received from the Purchase Agreement and proceeds received from the Notes offering. Pursuant to the Purchase Agreement entered into in September 2022, we received net cash proceeds of $124.4 million, after deducting issuance costs. In June 2026, we issued the Notes, whereby we received net cash proceeds of $128.0 million, after deducting issuance costs paid, costs to extinguish our revenue interest liability under the Purchase Agreement, fees paid for the capped call transactions and costs to repurchase 1,451,800 shares of our common stock. As of June 30, 2026, we had cash, cash equivalents and marketable securities of $356.7 million, excluding $15.1 million of cash and cash equivalents held by Digital Biotechnologies, Inc. We believe our existing cash, cash equivalents and marketable securities will be sufficient to fund our operating expenses and capital expenditure requirements through at least the next 12 months. We may consider raising additional capital to expand our business, to pursue strategic investments, to take advantage of financing opportunities or for other reasons. If our available cash, cash equivalents and marketable securities balances and anticipated cash flows are insufficient to satisfy our liquidity requirements, we may seek to sell additional equity or convertible debt securities, enter into a credit facility or another form of third-party funding or seek other debt financing. The sale of equity and convertible debt securities may result in dilution to our shareholders and, in the case of preferred equity securities or convertible debt, those securities could provide for rights, preferences or privileges senior to those of our common stock. The terms of debt securities issued or borrowings pursuant to a credit agreement could impose significant restrictions on our operations. This additional capital may not be available on reasonable terms, or at all. We plan to utilize the existing cash, cash equivalents and marketable securities on hand primarily to fund our commercial and assay development initiatives associated with clonoSEQ, our continued research and development initiatives related to mapping TCRs to antigens and the advancement of our target discovery capabilities. Cash in excess of immediate requirements is invested in accordance with our investment policy, primarily with a view to capital preservation and liquidity. Currently, our funds are held in money market funds and marketable securities consisting of U.S. government treasury and agency securities, commercial paper and corporate bonds. While we may experience variability in revenue in the near term, over the long term we expect revenue from our current and future products and services to grow. Accordingly, we expect our accounts receivable and inventory balances to increase. Our levels of accounts receivable may fluctuate relative to our revenue for a number of reasons, including the timing of milestone triggers and related payment of those milestones and an increase in revenue generated from clinical customers, which may result in more billings in arrears as opposed to upfront payments. Any increase in accounts receivable and inventory may not be completely offset by increases in accounts payable and accrued expenses, which could result in greater working capital requirements. Contractual Obligations In June 2026, we issued $345.0 million in aggregate principal amount of Notes. We used a portion of the proceeds from the Notes offering to extinguish our revenue interest liability under the Purchase Agreement. See Note 7, Leases, Note 8, Convertible Senior Notes and Capped Call Transactions and Note 9, Revenue Interest Purchase Agreement of the accompanying notes to the unaudited condensed consolidated financial statements included elsewhere in this report for more information regarding our contractual obligations relating to lease agreements, the Notes and the settlement of our obligations under the Purchase Agreement, respectively. There have been no other material changes outside the ordinary course of business to our contractual obligations and commitments as previously disclosed in our Annual Report on Form 10-K for the year ended December 31, 2025 (the “Annual Report”) filed with the SEC on February 26, 2026. Cash Flows The following table summarizes our uses and sources of cash for the six months ended June 30, 2026 and 2025 (in thousands): Six Months Ended June 30, 2026 2025 Net cash used in operating activities $ (15,937 ) $ (40,914 ) Net cash (used in) provided by investing activities (34,334 ) 28,919 Net cash provided by financing activities 149,688 7,061 Operating Activities Net cash used in operating activities was primarily comprised of net loss, as adjusted for noncash items, and changes in operating assets and liabilities. Noncash adjustments consist primarily of the loss recognized upon our early settlement of the Purchase Agreement and share-based compensation. 36 Adaptive Biotechnologies Corporation Net cash used in operating activities was $15.9 million as compared to $40.9 million for the six months ended June 30, 2026 and 2025, respectively. The decrease in net cash used in operating activities was primarily driven by an increase in customer collections, partially offset by an increase in interest payments. Investing Activities Net cash used in investing activities was $34.3 million as compared to $28.9 million net cash provided by investing activities for the six months ended June 30, 2026 and 2025, respectively. The increase in net cash used in investing activities was primarily due to a decrease in proceeds from maturities of marketable securities and an increase in purchases of marketable securities. Financing Activities Net cash provided by financing activities was $149.7 million as compared to $7.1 million for the six months ended June 30, 2026 and 2025, respectively. The increase in net cash provided by financing activities was primarily due to proceeds received from the Notes, an increase in proceeds from the exercise of stock options and proceeds received from Digital Biotechnologies, Inc.’s Series A Preferred Stock financing, partially offset by the revenue interest liability extinguishment, the purchase of capped calls and the repurchase of our common stock. Net Operating Loss Carryforwards Utilization of our net operating loss (“NOL”) carryforwards and credits may be subject to a substantial annual limitation due to the ownership change limitations provided by Section 382 of the Internal Revenue Code of 1986 (“Section 382”) and similar state provisions. The annual limitation may result in the expiration of NOL carryforwards and credits before utilization. If there should be an ownership change, our ability to utilize our NOL carryforwards and credits could be limited. We have completed a Section 382 analysis for changes in ownership through December 31, 2023 and continue to monitor for changes that could trigger a limitation. Based on this analysis, we do not expect to have any permanent limitations on the utilization of our federal NOLs. Under the Tax Cuts and Jobs Act of 2017, federal NOLs incurred in 2018 and future years may be carried forward indefinitely, but the deductibility of such federal NOLs is subject to an annual limitation. NOLs generated prior to 2018 are eligible to be carried forward up to 20 years. Based on the available objective evidence, management determined that it was more likely than not that the net deferred tax assets would not be realizable as of December 31, 2025. Accordingly, management applied a full valuation allowance against net deferred tax assets as of December 31, 2025. Critical Accounting Policies and Estimates We have prepared the unaudited condensed consolidated financial statements in accordance with GAAP. Our preparation of these unaudited condensed consolidated financial statements requires us to make certain estimates, judgments and assumptions that affect the reported amounts of assets and liabilities and the related disclosures at the date of the unaudited condensed consolidated financial statements, as well as the reported amounts of revenues and expenses recorded during the periods presented. We evaluate our estimates and judgments on an ongoing basis. We base our estimates on historical experience and other relevant assumptions that we believe to be reasonable under the circumstances. Estimates are used in several areas, including, but not limited to, estimates of progress to date for certain performance obligations and the transaction price for certain contracts with customers, imputing interest for the Purchase Agreement, the provision for income taxes, including related reserves, the analysis of goodwill impairment and the recoverability and impairment of long-lived assets, among others. These estimates generally involve complex issues and require judgments, involve the analysis of historical results and prediction of future trends, can require extended periods of time to resolve and are subject to change from period to period. Actual results may differ materially from management’s estimates. While our significant accounting policies are described in more detail in our Annual Report filed with the SEC on February 26, 2026, as well as in Note 2, Significant Accounting Policies of the accompanying notes to the unaudited condensed consolidated financial statements included elsewhere in this report, we believe the following accounting policies are critical to the judgments and estimates used in the preparation of the unaudited condensed consolidated financial statements: •revenue recognition; •goodwill; and •recoverability and impairment of long-lived assets. There have been no material changes to our critical accounting policies and estimates as previously disclosed in our Annual Report filed with the SEC on February 26, 2026. 37 Adaptive Biotechnologies Corporation Recent Accounting Pronouncements See Note 2, Significant Accounting Policies of the accompanying notes to the unaudited condensed consolidated financial statements included elsewhere in this report for more information.