Denali Therapeutics Inc.
A biotech company building medicines that can actually reach the brain to fight diseases like Alzheimer's and Parkinson's. Its signature "Transport Vehicle" technology rides drugs across the blood-brain barrier, the natural shield that keeps most treatments out. Three former Genentech scientists founded Denali in 2015, naming it after North America's tallest peak—the Athabascan word for "the high one"—to signal their ambition to conquer the hardest medical challenges.
Bought 275.0K
Sold 569.6K
Granted 33.9K
Sold 9.48M
Granted 5.3K
Granted 1.13M · Sold 1.42M
Granted 118.7K · Sold 877.5K
Granted 135.9K · Sold 368.6K
Granted 447.6K · Sold 460.8K
Granted 457.3K · Sold 429.8K
Granted 33.9K
Granted 18.2K · Sold 51.0K
Granted 81.1K · Sold 139.4K
Granted 33.9K
Granted 33.9K · Sold 1.5K
Granted 29.2K
Granted 15.5K
Granted 17.1K
Granted 17.0K
| Insider | Stake change | Holds now | Granted / vested | Bought | Sold |
|---|---|---|---|---|---|
| Bratton Douglas K +7 co-filers10% owner · 7 transactions | — | 18.06Mas of Dec 2017 | — | 275.0K | — |
| Bratton Douglas K +3 co-filers10% owner · 17 transactions | — | 12.20Mas of Dec 2020 | — | — | 569.6K |
| Bybee Clinton +4 co-filers10% owner · 2 transactions | — | 10.67Mas of Aug 2019 | — | — | — |
| Baker Bros. Advisors LP +5 co-filersDirector · 4 transactions | — | 10.57M | 33.9K | — | — |
| Bratton Douglas K +4 co-filers10% owner · 4 transactions | — | 10.53Mas of Feb 2021 | — | — | 9.48M |
| FMR LLCSee Remark 1 · 9 transactions | — | 9.74Mas of Dec 2017 | — | — | — |
| Nelsen RobertDirector · 9 transactions | — | 9.68Mas of Jun 2021 | 5.3K | — | — |
| Afeyan Noubar +2 co-filers10% owner · 1 transaction | — | 8.92Mas of Dec 2017 | — | — | — |
| FIL LtdSee Remark 1 · 21 transactions | — | 5.07Mas of Dec 2017 | — | — | — |
| Watts Ryan J.President and CEO, Director · 150 transactions | — | 2.45M | 1.13M | — | 1.42M |
| Tessier-Lavigne MarcDirector · 57 transactions | — | 2.12Mas of Jun 2025 | 118.7K | — | 877.5K |
| Krognes Steve E.Director · 50 transactions | — | 820.0K | 135.9K | — | 368.6K |
| Schuth Alexander O.COFO and Secretary · 148 transactions | — | 806.6K | 447.6K | — | 460.8K |
| Ho CaroleChief Medical Officer · 139 transactions | — | 449.8Kas of Aug 2025 | 457.3K | — | 429.8K |
| Flatley Jay TDirector · 8 transactions | — | 358.9K | 33.9K | — | — |
| Sato Vicki LDirector · 55 transactions | — | 108.0Kas of Jan 2025 | 18.2K | — | 51.0K |
| Schenkein David PDirector · 19 transactions | — | 79.1K | 81.1K | — | 139.4K |
| Klein Peter SDirector · 7 transactions | — | 33.9K | 33.9K | — | — |
| Cook Jennifer E.Director · 8 transactions | — | 32.5K | 33.9K | — | 1.5K |
| Thornberry NancyDirector · 6 transactions | — | 31.1K | 29.2K | — | — |
| Cole Douglas G.Director · 4 transactions | — | 26.6Kas of Jun 2023 | 15.5K | — | — |
| Harris ErikDirector · 3 transactions | — | 17.1Kas of May 2024 | 17.1K | — | — |
| Van Hauwermeiren TimothyDirector · 2 transactions | — | 17.0K | 17.0K | — | — |
Select a row to see that insider’s individual transactions. Sum of the holdings confirmed in the 12 months before this insider's last filing. A Form 4 reports a holding per line — held directly, or through a named trust, partnership or foundation, and in each share class separately — never a person’s total. Lines not restated in that time are left out and shown apart: an active filer restates what they still hold, so a line they did not restate is more often an entity since renamed, whose shares a successor line reports too. An amber marker means some were left out.
Net open-market activity over all recorded history: -13.52M shares. Grants, option exercises and tax withholding are excluded — they are compensation mechanics, not decisions to buy or sell.